Thermodynamics of the Formation of Transition Metal Complexes Carrying Adenosine Drug in Mixed Solvent System
نویسنده
چکیده
In the present work we investigate the stability constant of Adenosine drug with transition metal ions Fe, Co, Ni, Cu, Zn, and Cd using a pH metric titration technique in 20% (v/v) ethanol-water mixture at three different temperatures (25 °C, 35 °C, and 45 °C) and at an ionic strength of 0.1M NaClO4. The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine metal-ligand stability constant logK values. It is observed that transition metal ion forms 1:1 and 1:2 complexes. The trend in the formation constants follows the order: Fe 3+ > Cu 2+ > Zn 2+ > Ni 2+ > Co 2+ > Cd 2+ . The thermodynamic parameters such as, Gibb’s free energy change (∆G), entropy change (∆S) and enthalpy change (∆H) associated with the complexation reactions were calculated. The formations of metal complexes were found to be spontaneous, exothermic in nature and favorable at lower temperature.
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